微信在线咨询
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM8016-10mM | 表儿茶素(98%, HPLC) | 10mM×0.2ml | 75.00元 |
| SM8016-25mg | 表儿茶素(98%, HPLC) | 25mg | 120.00元 |
| SM8016-100mg | 表儿茶素(98%, HPLC) | 100mg | 408.00元 |
| 中文名 | 表儿茶素 |
| 英文名 | (-)-Epicatechin |
| 中文别名 | (-)-表儿茶素；表儿茶精；表儿茶酚 |
| 英文别名 | Epicatechin; (-)-Epicatechol; epi-Catechin; Epicatechol; Teacatechin I; Acacatechin; Kakaol; Colatein |
| 来源 | 儿茶Acacia catechu (L. f.) Willd. |
| 化合物类型 | 酚类(Phenols) |
| 化学式 | C15H14O6 |
| 分子量 | 290.27 |
| CAS号 | 490-46-0 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: 100 mg/ml (344.51 mM) |
| 溶液配制 | 5mg加入1.72ml DMSO，或者每2.90mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | (-)-Epicatechin inhibits cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB. | ||||
| 信号通路 | NF-κB | ||||
| 靶点 | COX-1 | - | - | - | - |
| IC50 | 3.2 μM | - | - | - | - |
| 体外研究 | (-)-Epicatechin exhibits >95% inhibitory activity at 70 μg/ml against cyclooxygenase-1 (COX-1) with an IC50 of 3.2 μM. (-)-Epicatechin inhibits the IL-1β-induced expression of iNOS by blocking the nuclear localization of the p65 subunit of NF-κB. In RINm5F cells, (-)-Epicatechin is shown to block the inhibition of insulin release after addition of IL-1β. Additionally, (-)-Epicatechin is shown to inhibit the proliferation of Hodgkin's lymphoma cells and Jurkat T cells, which is attributed to the ability of (-)-Epicatechin to inhibit the binding of NF-κB to DNA in these cells. In human colorectal cancer HCT-116 cells, combining 20 μM Panaxadiol with 150, 200, or 250 μM (-)-Epicatechin results in growth inhibition of 51%, 97%, and 95%, respectively. The combination also increases the apoptosis level by 11.9%, 16.6%, and 25.8%, as examined by annexin V/PI staining. | ||||
| 体内研究 | Animals receive 1 mg/kg of (-)-Epicatechin or water (vehicle) via oral gavage (twice daily). Exercise groups undergo 15 days of treadmill exercise. Significant increases in treadmill performance (~50%) and enhanced in situ muscle fatigue resistance (~30%) are observed with (-)-Epicatechin. | ||||
| 临床实验 | NCT01690676: Borderline Hypertension, Phase 2; NCT02964377: Duchenne Muscular Dystrophy, Phase 1|Phase 2. | ||||
1.Waffo-Téguo P, et al. Nutr Cancer. 2001,40(2):173-9.
2.Shay J, et al. Oxid Med Cell Longev. 2015:181260.
3.Nogueira L, et al. J Physiol. 2011,589(Pt 18):4615-31.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM8016-10mM | 表儿茶素(98%, HPLC) | 10mM×0.2ml |
| SM8016-25mg | 表儿茶素(98%, HPLC) | 25mg |
| SM8016-100mg | 表儿茶素(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃保存，至少一年有效。固体粉末4℃保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
微信在线咨询
