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| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| SM8028-10mM | 儿茶素(98%, HPLC) | 10mM×0.2ml | 73.00元 |
| SM8028-25mg | 儿茶素(98%, HPLC) | 25mg | 96.00元 |
| SM8028-100mg | 儿茶素(98%, HPLC) | 100mg | 326.00元 |
| 中文名 | 儿茶素 |
| 英文名 | Catechin |
| 中文别名 | (+)-儿茶素 |
| 英文别名 | (+)-Catechin; Cianidanol; Catechuic acid; Dexcyanidanol; Cianidol; Catergen; Drenoliver; Biocatechin; Tanningenic acid; Cyanidol |
| 来源 | 儿茶Acacia catechu (L. f.) Willd. |
| 化合物类型 | 酚类(Phenols) |
| 化学式 | C15H14O6 |
| 分子量 | 290.27 |
| CAS号 | 154-23-4 |
| 纯度 | 98%, HPLC |
| 溶剂/溶解度 | DMSO: ≥ 100 mg/ml (344.51 mM) |
| 溶液配制 | 5mg加入1.72ml DMSO，或者每2.90mg加入1ml DMSO，配制成10mM溶液。 |
| 产品描述 | Catechin ((+)-Catechin) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. | ||||
| 信号通路 | - | ||||
| 靶点 | COX-1 | p53 | Caspase-3 | Caspase-8 | Caspase-9 |
| IC50 | 1.4 μM | - | - | - | - |
| 体外研究 | Catechin ((+)-Catechin) exhibits >95% inhibitory activity at 70 μg/ml against cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. A dose-dependent reduction in color is observed after 24 hours of treatment with Catechin, and 54.76% of the cells are dead at the highest concentration of Catechin tested (160 μg/ml) whereas the IC50 of Catechin is achieved at 127.62 μg/ml Catechin. A dose- and time-dependent increase in the induction of apoptosis is observed when MCF-7 cells are treated with Catechin. When compare to the control cells at 24 hours, 40.7 and 41.16% of the cells treated with 150 μg/ml and 300 μg/ml Catechin, respectively, undergo apoptosis. The expression levels of Caspase-3, -8, and -9 and p53 in MCF-7 cells treated with 150 μg/ml Catechin for 24 h increase by 5.81, 1.42, 3.29, and 2.68 fold, respectively, as compare to the levels in untreated control cells. | ||||
| 体内研究 | Animals treated with Catechin ((+)-Catechin) at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with Catechin prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively). | ||||
| 临床实验 | NCT01082302: Genital Warts|Perianal Warts, Phase 4. | ||||
1.Waffo-Téguo P, et al. Nutr Cancer. 2001,40(2):173-9.
2.Cheruku SP, et al. Cytotechnology. 2018,70(1):245-259.
3.Alshatwi AA. J Exp Clin Cancer Res. 2010,29:167.
包装清单：| 产品编号 | 产品名称 | 包装 |
| SM8028-10mM | 儿茶素(98%, HPLC) | 10mM×0.2ml |
| SM8028-25mg | 儿茶素(98%, HPLC) | 25mg |
| SM8028-100mg | 儿茶素(98%, HPLC) | 100mg |
| － | 说明书 | 1份 |
-20℃避光保存，至少一年有效。固体粉末4℃避光保存，至少一个月有效。如果溶于非DMSO溶剂，建议分装后-80℃避光保存，预计6个月内有效。
注意事项：本产品可能对人体有一定的毒害作用，请注意适当防护，以避免直接接触人体或吸入体内。
本产品仅限于专业人员的科学研究用，不得用于临床诊断或治疗，不得用于食品或药品，不得存放于普通住宅内。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
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