使用说明：
1. 通常细胞增殖实验每孔加入100微升2000个细胞，细胞毒性实验每孔加入100微升5000个细胞(具体每孔所
   用的细胞的数目，需根据细胞的大小、细胞增殖速度的快慢等因素决定)。按照实验需要，进行培养并给
   予0-10微升特定的药物刺激。
2. 每孔加入10微升CCK-8溶液。如果起始的培养体积为200微升，则需加入20微升CCK-8溶液，其它情况以此
   类推。可以用加了相应量细胞培养液和CCK-8溶液但没有加入细胞的孔作为空白对照。如果担心所使用的
   药物会干扰检测，需设置加了相应量细胞培养液、药物和CCK-8溶液但没有加入细胞的孔作为空白对照。
3. 在细胞培养箱内继续孵育0.5-4小时，对于大多数情况孵育1小时就可以了。时间的长短根据细胞的类型
   和细胞的密度等实验情况而定，初次实验时可以在0.5、1、2和4小时后分别用酶标仪检测，然后选取吸
   光度范围比较适宜的一个时间点用于后续实验。
4. 在450nm测定吸光度。如无450nm滤光片，可以使用420-480nm的滤光片。可以使用大于600nm的波长，例
   如650nm，作为参考波长进行双波长测定。
常见问题：
1. CCK-8溶液对细胞的毒性大小如何？
   CCK-8溶液对细胞的毒性非常低，通常观察不到细胞毒性。细胞在CCK-8法检测后仍然可以正常生长，并
   可以用于其它的细胞实验。但为了避免CCK-8溶液可能带来的对于后续检测的影响，除非该细胞极难获
   得，否则不推荐把CCK-8溶液孵育过的细胞用于其它实验。
2. 如果吸光度值太低，可以采取什么办法？
   a. 适当增加细胞数量。
   b. 延长加入CCK-8试剂后的孵育时间。
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86.He H, Yang T, Jia S, Zhang R, Tu P, Gao J, Yuan Y, Han W, Yu Y.
   Expression and purification of bioactive high-purity human S100A6 in Escherichia coli.
   Protein Expr Purif. 2012 May;83(1):98-103. doi: 10.1016/j.pep.2012.03.002.
   Epub 2012 Mar 17.
87.Shao X, Hu Z, Hu C, Bu Q, Yan G, Deng P, Lv L, Wu D, Deng Y, Zhao J, Zhu R, Li Y, Li H,
   Xu Y, Yang H, Zhao Y, Cen X.
   Taurine protects methamphetamine-induced developmental angiogenesis defect through
   antioxidant mechanism.
   Toxicol Appl Pharmacol. 2012 May 1;260(3):260-70. doi: 10.1016/j.taap.2012.03.003.
   Epub 2012 Mar 9.
88.Zhang L, Yang M, Gan L, He T, Xiao X, Stewart MD, Liu X, Yang L, Zhang T, Zhao Y, Fu J.
   DLX4 upregulates TWIST and enhances tumor migration, invasion and metastasis.
   Int J Biol Sci. 2012;8(8):1178-87. doi: 10.7150/ijbs.4458. Epub 2012 Oct 13.
89.Sun Q, Kawamura T, Masutani K, Peng X, Sun Q, Stolz DB, Pribis JP, Billiar TR, Sun X,
   Bermudez CA, Toyoda Y, Nakao A.
   Oral intake of hydrogen-rich water inhibits intimal hyperplasia in arterialized vein
   grafts in rats.
   Cardiovasc Res. 2012 Apr 1;94(1):144-53. doi: 10.1093/cvr/cvs024. Epub 2012 Jan 27.
90.Li X, Zheng SL, Li X, Li JL, Qiang O, Liu R, He L.
   Synthesis and anti-breast cancer activity of new indolylquinone derivatives.
   Eur J Med Chem. 2012 Aug;54:42-8. doi: 10.1016/j.ejmech.2012.04.019. Epub 2012 May 8.
91.Ning L, Li X, Ding X, Yin Y, Li G.
   An iRGD Based Strategy to Study Electrochemically the Species Inside a Cell.
   Int J Mol Sci. 2012;13(8):10424-31. doi: 10.3390/ijms130810424. Epub 2012 Aug 21.
92.Zhou X, Meng Q, Xu X, Zhi T, Shi Q, Wang Y, Yu R.
   Bex2 regulates cell proliferation and apoptosis in malignant glioma cells via the c-Jun
   NH2-terminal kinasepathway.
   Biochem Biophys Res Commun.2012 Oct 26;427(3):574-80.doi:10.1016/j.bbrc.2012.09.
   100. Epub 2012 Sep 26.
93.Xie Y, Liao J, Li M, Wang X, Yang Y, Ge J, Chen R, Chen H.
   Impaired cardiac microvascular endothelial cells function induced by Coxsackievirus B3
   infection and its potentialrole in cardiac fibrosis.
   Virus Res. 2012 Oct;169(1):188-94. doi: 10.1016/j.virusres.2012.07.027.
   Epub 2012 Aug 4.
94.Wang W, Tao R, Tong Z, Ding Y, Kuang R, Zhai S, Liu J, Ni L.
   Effect of a novel antimicrobial peptide chrysophsin-1 on oral pathogens and
   Streptococcus mutans biofilms.
   Peptides.2012 Feb;33(2):+212-9.doi:10.1016/j.peptides.2012.01.006.Epub 2012 Jan 20.
95.Du X, Zhao B, Li J, Cao X, Diao M, Feng H, Chen X, Chen Z, Zeng X.
   Astragalus polysaccharides enhance immune responses of HBV DNA vaccination via promoting
   the dendritic cell maturation and suppressing Treg frequency in mice.
   Int Immunopharmacol. 2012 Dec;14(4):463-70. doi: 10.1016/j.intimp.2012.09.006.
   Epub 2012 Sep 21.
96.Zhou BR, Yin HB, Xu Y, Wu D, Zhang ZH, Yin ZQ, Permatasari F, Luo D.
   Baicalin protects human skin fibroblasts from ultraviolet A radiation-induced oxidative
   damage and apoptosis.
   Free Radic Res. 2012 Dec;46(12):1458-71. doi: 10.3109/10715762.2012.726355.
   Epub 2012 Sep 24.
97.Wu Q, Wang C, Guo L, Ge Q, Lu Z.
   Identification and characterization of novel microRNA candidates from deep sequencing.
   Clin Chim Acta. 2013 Jan 16;415:239-44. doi: 10.1016/j.cca.2012.11.002.
   Epub 2012 Nov 12.
98.Hu Y, Qi Y, Liu H, Fan G, Chai Y.
   Effects of celastrol on human cervical cancer cells as revealed by ion-trap gas
   chromatography-mass spectrometry based metabolic profiling.
   Biochim Biophys Acta. 2013 Mar;1830(3):2779-89.
99.Shen XL, Zhang Y, Xu W, Liang R, Zheng J, Luo Y, Wang Y, Huang K.
   An iTRAQ-based mitoproteomics approach for profiling the nephrotoxicity mechanisms of
   ochratoxin A in HEK293 cells.
   J Proteomics.2013 Jan 14;78:398-415.doi:10.1016/j.jprot.2012.10.010.Epub 2012 Oct 23.
100.Su Y, Xu JJ, Bi JL, Wang YH, Hu GW, Yang J, Yin GF, Long CL.
   Chemical constituents of Arisaema franchetianum tubers.
   J Asian Nat Prod Res. 2013;15(1):71-7. doi: 10.1080/10286020.2012.723202.
   Epub 2012 Oct 29.
101.Guo Z, Zhou B, Liu W, Xu Y, Wu D, Yin Z, Permatasari F, Luo D.
   MiR-23a regulates DNA damage repair and apoptosis in UVB-irradiated HaCaT cells.
   J Dermatol Sci. 2013 Jan;69(1):68-76. doi: 10.1016/j.jdermsci.2012.10.014.
   Epub 2012 Oct 30.
102.Ma GF, Chen SY, Sun ZR, Miao Q, Liu YM, Zeng XQ, Luo TC, Ma LL, Lian JJ, Song DL.
   FoxP3 inhibits proliferation and induces apoptosis of gastric cancer cells by activating
   the apoptotic signalingpathway.
   Biochem Biophys Res Commun.2013 Jan 11;430(2):804-9.doi:10.1016/j.bbrc.2012.11.065.
103.Zhao L, Wang H, Huo K, Zhang X, Wang W, Zhang Y, Wu Z, Chu PK.
   The osteogenic activity of strontium loaded titania nanotube arrays on titanium
   substrates.
   Biomaterials. 2013 Jan;34(1):19-29. doi: 10.1016/j.biomaterials.2012.09.041.
   Epub 2012 Oct 6.
104.Pang H, Wu XH, Fu SL, Luo F, Zhang ZH, Hou TY, Li ZQ, Chang ZQ, Yu B, Xu JZ.
   Co-culture with endothelial progenitor cells promotes survival, migration, and
   differentiation of osteoclastprecursors.
   Biochem Biophys Res Commun.2013 Jan 11;430(2):729-34.
   doi:10.1016/j.bbrc.2012.11.081. Epub 2012 Dec 1.
105.Gao C, Cai Y, Kong X, Han G, Yao J.
   Development and characterization of injectable chitosan-based hydrogels containing
   dexamethasone/rhBMP-2 loaded hydroxyapatite nanoparticles.
   Materials Letters.Volume 93, 15 February 2013, Pages 312–315.
106.Chang Y, Huang X, Liu Z, Han G, Huang L, Xiong YC, Wang Z.
   Dexmedetomidine inhibits the secretion of high mobility group box 1 from
   lipopolysaccharide-activatedmacrophages in vitro.
   J Surg Res. 2013 May;181(2):308-14. doi: 10.1016/j.jss.2012.07.017. Epub 2012 Jul 26.
107.Wang Y, Wang K, Li H, Chen L, Xu F, Wu T.
   Effects of different sustained hydrostatic pressures on connexin 43 in human bladder
   smooth muscle cells.
   Urol Int. 2013;90(1):75-82. doi: 10.1159/000338924. Epub 2012 Dec 19.
108.Li Y, Wang Y, Wang P, Zhang B, Yan W, Sun J, Pan J.
   In vitro cytocompatibility evaluation of MGF-Ct24E chemically grafted and physically
   blended with maleicanhydride modified poly(D, L-lactic acid).
   J Biomater Sci Polym Ed. 2013;24(7):849-64. doi: 10.1080/09205063.2012.723957.
   Epub 2012 Sep 11.
109.Alibrahim A, Zhao LY, Bae CY, Barszczyk A, Sun CL, Wang GL, Sun HS.
   Neuroprotective effects of volume-regulated anion channel blocker DCPIB on neonatal
   hypoxic-ischemic injury.
   Acta Pharmacol Sin. 2013 Jan;34(1):113-8. doi: 10.1038/aps.2012.148. Epub 2012 Dec 3.
110.Shu G, Xie B, Ren F, Liu DC, Zhou J, Li Q, Chen J, Yuan L, Zhou J.
   Restoration of klotho expression induces apoptosis and autophagy in hepatocellular
   carcinoma cells.
   Cell Oncol (Dordr).2013 Apr;36(2):121-9.doi:10.1007/s13402-012-0118-0.
   Epub 2012 Dec 18.
111.Kuang P, Zhao W, Su W, Zhang Z, Zhang L, Liu J, Ren G, Yin Z, Wang X.
   18β-glycyrrhetinic acid inhibits hepatocellular carcinoma development by reversing
   hepatic stellate cell-mediatedimmunosuppression in mice.
   Int J Cancer. 2013 Apr 15;132(8):1831-41. doi: 10.1002/ijc.27852. Epub 2012 Oct 20.
112.Liu Z, Chang Y, Zhang J, Huang X, Jiang J, Li S, Wang Z.
   Magnesium deficiency promotes secretion of high-mobility group box 1 protein from
   lipopolysaccharide-activatedmacrophages in vitro.
   J Surg Res. 2013 Apr;180(2):310-6. doi: 10.1016/j.jss.2012.04.045. Epub 2012 May 10.
113.Zhang M, Qiu Z, Li Y, Yang Y, Zhang Q, Xiang Q, Su Z, Huang Y.
   Construction and characterization of a recombinant human beta defensin 2 fusion protein
   targeting the epidermalgrowth factor receptor: in vitro study.
   Appl Microbiol Biotechnol. 2013 May;97(9):3913-23. doi: 10.1007/s00253-012-4257-z.
   Epub 2012 Aug 5.
114.Ji X, Lu W, Zhou H, Han D, Yang L, Wu H, Li J, Liu H, Zhang J, Cao P, Zhang S.
   Covalently dimerized Camelidae antihuman TNFa single-domain antibodies expressed in
   yeast Pichia pastorisshow superior neutralizing activity.
   Appl Microbiol Biotechnol. 2013 Jan 17. [Epub ahead of print].
115.Shan D, Shi Y, Duan S, Wei Y, Cai Q, Yang X.
   Electrospun magnetic poly(l-lactide) (PLLA) nanofibers by incorporating PLLA-stabilized
   Fe3O4 nanoparticles.
   Mater Sci Eng C Mater Biol Appl. 2013 Aug 1;33(6):3498-505.
   doi:10.1016/j.msec.2013.04.040. Epub 2013 Apr 26.
116.Xie H, Li J, Li L, Dong Y, Chen GQ, Chen KC.
   Enhanced proliferation and differentiation of neural stem cells grown on PHA films
   coated with recombinantfusion proteins.
   Acta Biomater. 2013 Apr 29. pii: S1742-7061(13)00219-5.
   doi: 10.1016/j.actbio.2013.04.038. [Epub ahead of print].
117.Liu W, Lin J, Cheng Y, Zhang L , Huang J, Wu Z, Wang F, Xu S, Lin W, Lan W, Yang G.
   FIM-A, a Phosphorus-Containing Sirolimus, Inhibits the Angiogenesis and Proliferation of
   Osteosarcomas.
   Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics,
   Volume 20, Number 7, 2013 , pp. 319-326(8) .
118.Wang H, Jiang W, Yuan L, Wang L, Chen H.
   Reductase-like activity of silicon nanowire arrays.
   ACS Appl Mater Interfaces. 2013 Mar 13;5(5):1800-5. doi: 10.1021/am3031322.
   Epub 2013 Feb 20.
119.Zhan XX, Liu Y, Yang JF, Wang GY, Mu L, Zhang TS, Xie XL, Wang JH, Liu YM, Kong QF,
   Li HL, Sun B.Immunology.
   All-trans-retinoic acid ameliorates experimental allergic encephalomyelitis by affecting
   dendritic cell and monocytedevelopment.
   Immunology. 2013 Apr;138(4):333-45. doi: 10.1111/imm.12040.
120.Bai J, Mei P, Zhang C, Chen F, Li C, Pan Z, Liu H, Zheng J.
   BRG1 is a prognostic marker and potential therapeutic target in human breast cancer.
   PLoS One. 2013;8(3):e59772. doi: 10.1371/journal.pone.0059772. Epub 2013 Mar 22.
121.Feng H, Du X, Tang J, Cao X, Han X, Chen Z, Chen Y, Zeng X.
   Enhancement of the immune responses to foot-and-mouth disease vaccination in mice by
   oral administration of a Novel polysaccharide from the roots of Radix Cyathulae
   officinalis Kuan (RC).
   Cell Immunol. 2013 Feb;281(2):111-21. doi: 10.1016/j.cellimm.2013.02.004.
   Epub 2013 Mar 13.
122.Yang Q, Sui G, Shi Y, Duan S, Bao J, Cai Q, Yang X.
   Osteocompatibility characterization of polyacrylonitrile carbon nanofibers containing
   bioactive glass nanoparticles.
   Carbon.Volume 56, May 2013, Pages 288–295.
123.Hu J, Zhang L, Wang N, Ding R, Cui S, Zhu F, Xie Y, Sun X, Wu D, Hong Q, Li Q, Shi S,
   Liu X, Chen X.
   Mesenchymal stem cells attenuate ischemic acute kidney injury by inducing regulatory T
   cells through splenocyteinteractions.
   Kidney Int. 2013 Apr 24. doi: 10.1038/ki.2013.114. [Epub ahead of print].
124.Wang S, Pang T, Gao M, Kang H, Ding W, Sun X, Zhao Y, Zhu W, Tang X, Yao Y, Hu X.
   HPV E6 induces eIF4E transcription to promote the proliferation and migration of
   cervical cancer.
   FEBS Lett.2013 Mar 18;587(6):690-7.doi:10.1016/j.febslet.2013.01.042.Epub 2013 Feb 11.
125.Yang L, Zhou L, Zong X, Cao X, Ji X, Gu W, Zhang S.
   Characterization of the molecular structure, expression and bioactivity of the TNFSF13B
   (BAFF) gene of the SouthAfrican clawed frog, Xenopus laevis.
   Int Immunopharmacol.2013 Mar;15(3):478-87.doi:10.1016/j.intimp.2013.02.006.
   Epub 2013 Feb 19.
126.Wu K, Song W, Zhao L, Liu M, Yan J, Andersen MØ, Kjems J, Gao S, Zhang Y.
   MicroRNA functionalized microporous titanium oxide surface by lyophilization with
   enhanced osteogenic activity.
   ACS Appl Mater Interfaces. 2013 Apr 10;5(7):2733-44. doi: 10.1021/am400374c.
   Epub 2013 Mar 21.
127.Yao W, Cai X, Liu C, Qin Y, Cheng H, Ji S, Xu W, Wu C, Chen T, Xu J, Long J, Fang Z,
   Qu B, Hoth M, Ni Q, Zha X, Yu X.
   Profilin 1 potentiates apoptosis induced by staurosporine in cancer cells.
   Curr Mol Med. 2013 Mar;13(3):417-28.
128.Bai J, Yong HM, Chen FF, Mei PJ, Liu H, Li C, Pan ZQ, Wu YP, Zheng JN.
   Cullin1 is a novel marker of poor prognosis and a potential therapeutic target in human
   breast cancer.
   Ann Oncol. 2013 Apr 16. [Epub ahead of print].
129.Zou X, Yu C, Zhang H.
   In Vitro Analyses of Effect of Light on Toxicity of Titanium Dioxide Nanoparticles to
   Tetrahymena Pyriformis Using Fourier Transform Infrared Spectra.
   An International Journal for Rapid Communication. Volume 46, Issue 8, 2013.
130.Xu D, Yang W, Hu Y, Luo Z, Li J, Hou Y, Liu Y, Cai K.
   Surface functionalization of titanium substrates with cecropin B to improve their
   cytocompatibility and reduceinflammation responses.
   Colloids Surf B Biointerfaces.2013 May 9;110C:225-235.
   doi:10.1016/j.colsurfb.2013.04.050. [Epub ahead of print].
131.Shen Z, Jiang X, Zeng C, Zheng S, Luo B, Zeng Y, Ding R, Jiang H, He Q, Guo J, Jie W.
   High expression of ubiquitin-conjugating enzyme 2C (UBE2C) correlates with
   nasopharyngeal carcinomaprogression.
   BMC Cancer. 2013 Apr 15;13:192. doi: 10.1186/1471-2407-13-192.
132.Jia D, Duan F, Peng P, Sun L, Liu X, Wang L, Wu W, Ruan Y, Gu J.
   Up-regulation of RACK1 by TGF-β1 promotes hepatic fibrosis in mice.
   PLoS One. 2013;8(3):e60115. doi: 10.1371/journal.pone.0060115. Epub 2013 Mar 29.
133.Zhu C, Qin H, Cheng T, Tan HL, Guo YY, Shi SF, Chen DS, Zhang XL.
   Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from
   osteoblasts via the p38MAPK and NF-κB pathways.
   Int J Mol Med. 2013 Jun;31(6):1484-94. doi: 10.3892/ijmm.2013.1346. Epub 2013 Apr 15.
134.Zhang X, Cai Z, Wang G, Wang H, Liu Z, Guo X, Yang C, Wang X, Wang H, Shu C, Xiao L.
   F-actin may play an important role in IL-1β-stimulated hippocampal neurons.
   Behav Brain Res.2013 Apr15;243:165-70.doi:10.1016/j.bbr.2013.01.001.Epub 2013 Jan 11.
135.Wang Q, Shen L, Huang W, Song Y, Xiao L, Xu W, Liu Y.
   Vasculogenesis of decidua side population cells of first-trimester pregnancy.
   Stem Cell Res Ther. 2013 May 7;4(3):50. [Epub ahead of print].
136.Zhen Y, Ye Y, Yu X, Mai C, Zhou Y, Chen Y, Yang H, Lyu X, Song Y, Wu Q, Fu Q, Zhao M,
   Hua S, Wang H, Liu Z, Zhang Y, Fang W.
   Reduced CTGF Expression Promotes Cell Growth, Migration, and Invasion in Nasopharyngeal
   Carcinoma.
   PLoS One. 2013 Jun 3;8(6):e64976. doi: 10.1371/journal.pone.0064976. Print 2013.
137.Shi SF, Zhang XL, Zhu C, Chen DS, Guo YY.
   Ultrasonically enhanced rifampin activity against internalized Staphylococcus aureus.
   Exp Ther Med. 2013 Jan;5(1):257-262. Epub 2012 Oct 22.
138.Duan S, Yang X, Mao J, Qi B, Cai Q, Shen H, Yang F, Deng X, Wang S.
   Osteocompatibility evaluation of poly (glycine ethyl ester-co-alanine ethyl ester)
   phosphazene with honeycomb-patterned surface topography.
   J Biomed Mater Res A.2013Feb;101(2):307-17.doi:10.1002/jbm.a.34282.Epub 2012 Jun 26.
139.Li G, Liu Y, Su Z, Ren S, Zhu G, Tian Y, Qiu Y.
   MicroRNA-324-3p regulates nasopharyngeal carcinoma radioresistance by directly
   targeting WNT2B.
   Eur J Cancer.2013 Apr 10.pii S0959-8049(13)00186-X.doi:10.1016/j.ejca.2013.03.001.
   [Epub ahead of print].
140.Jiao Q, Wang H, Hu Z, Zhuang Y, Yang W, Li M, Yu X, Liang J, Guo Y, Zhang H, Chen X,
   Cheng R, Yao Z.
   Lidocaine inhibits staphylococcal enterotoxin-stimulated activation of peripheral blood
   mononuclear cells frompatients with atopic dermatitis.
   Arch Dermatol Res. 2013 Apr 16. [Epub ahead of print].
141.Xu Y, Wu J, Wang H, Li H, Di N, Song L, Li S, Li D, Xiang Y, Liu W, Mo X, Zhou Q.
   Fabrication of Electrospun Poly(L-Lactide-co-ε-Caprolactone)/Collagen Nanoyarn Network
   as a Novel, Three-Dimensional, Macroporous, Aligned Scaffold for Tendon Tissue
   Engineering.
   Tissue Eng Part C Methods. 2013 May 21. [Epub ahead of print].
142.Lv L, Liu H, Chen X, Yang Z.
   Glutathione-triggered formation of molecular hydrogels for 3D cell culture.
   Colloids Surf B Biointerfaces.2013 Aug 1;108:352-7.doi:10.1016/j.colsurfb.
   2013.03.013. Epub 2013 Mar 21.
143.Xia J, Wang F, Wang L, Fan Q.
   Elevated serine protease HtrA1 inhibits cell proliferation, reduces invasion, and
   induces apoptosis in esophageal squamous cell carcinoma by blocking the nuclear
   factor-κB signaling pathway.
   Tumour Biol. 2013 Feb;34(1):317-28. doi: 10.1007/s13277-012-0553-6. Epub 2012 Oct 19.
144.Jiang ZQ, Yan XJ, Bi L, Chen JP, Zhou Q, Chen WP.
   Mechanism for hepato-protective action of Liangxue Huayu Recipe (LHR): Blockade of
   mitochondrial cytochrome c release and caspase activation.
   J Ethnopharmacol.2013 May 24.pii:S0378-8741(13)00360-7.doi:10.1016/j.jep.2013.05.024.
   [Epub ahead of print].
145.Wu S, Ju GQ, Du T, Zhu YJ, Liu GH.
   Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells
   attenuate bladdertumor cell growth in vitro and in vivo.
   PLoS One. 2013 Apr 12;8(4):e61366. doi: 10.1371/journal.pone.0061366. Print 2013.
146.Yang C, Wu D, Jia J, Liu D, Li Z, Zhang C, Li M, Xia Y.
   DLC1 as a regulator of proliferation, invasion, cell cycle, and apoptosis in cutaneous
   squamous cell carcinoma.
   Tumour Biol. 2013 Apr 28. [Epub ahead of print].
147.Zhou X, Qian J, Hua L, Shi Q, Liu Z, Xu Y, Sang B, Mo J, Yu R.
   Geranylgeranyltransferase I promotes human glioma cell growth through Rac1 membrane
   association andactivation.
   J Mol Neurosci.2013 Jan;49(1):130-9.doi:10.1007/s12031-012-9905-3.Epub 2012 Oct 17.
148.Jin Y, Peng D, Shen Y, Xu M, Liang Y, Xiao B, Lu J.
   MicroRNA-376c Inhibits Cell Proliferation and Invasion in Osteosarcoma by Targeting to
   Transforming GrowthFactor-Alpha.
   DNA Cell Biol. 2013 Jun;32(6):302-9. doi: 10.1089/dna.2013.1977. Epub 2013 Apr 30.
149.Hu X , Liu R, Zhu N.
   Enhancement of humoral and cellular immune responses by monophosphoryl lipid A (MPLA) as
   an adjuvant to the rabies vaccine in BALB/c mice.
   Immunobiology.Available online 30 May 2013.
150.Xia L, Huang Q, Shi J, Nie D, Gong M, Gong P, Zhao L, Zuo H, Huang H, Ju S, Chen J,
   Shi W.
   PAX3 is overexpressed in human glioblastomas and critically regulates the tumorigenicity
   of glioma cells.
   Brain Res. 2013 May 20.pii: S0006-8993(13)00696-3.doi:10.1016/j.brainres.2013.05.021.
151.Han Y, Guo XH, Zheng QF, Zhu YL, Fan YY, Zhang XY.
   Down-regulation of platelet-derived growth factor-D expression blockades NF-κB pathway
   to inhibit cellproliferation and invasion as well as induce apoptosis in esophageal
   squamous cell carcinoma.
   Mol Biol Rep.2013 Mar;40(3):2473-83.doi:10.1007/s11033-012-2328-y.Epub 2012 Nov 28.
152.Wang L, Liang B, Li L, Liu W.
   Induction of HepG2 cell apoptosis by Irgarol 1051 through mitochondrial dysfunction and
   oxidative stresses.
   Toxicol In Vitro.2013 May 28.pii:S0887-2333(13)00132-X.doi:10.1016/j.tiv.2013.05.006.
153.Gao F, Ding B, Zhou L, Gao X, Guo H, Xu H.
   Magnesium sulfate provides neuroprotection in lipopolysaccharide-activated primary
   microglia by inhibiting NF-κB pathway.
   J Surg Res. 2013 Apr 6. pii: S0022-4804(13)00228-X. doi: 10.1016/j.jss.2013.03.034.
   [Epub ahead of print].
154.Chen Q, Xue Y, Sun J.
   Kupffer cell-mediated hepatic injury induced by silica nanoparticles in vitro and in
   vivo.
   Int J Nanomedicine. 2013;8:1129-40. doi: 10.2147/IJN.S42242. Epub 2013 Mar 15.
155.Chen F, Bai J, Li W, Mei P, Liu H, Li L, Pan Z, Wu Y, Zheng J.
   RUNX3 suppresses migration, invasion and angiogenesis of human renal cell carcinoma.
   PLoS One. 2013;8(2):e56241. doi: 10.1371/journal.pone.0056241. Epub 2013 Feb 14.
156.Chen Q, Sun J.
   Implication of Oxidative Stress in Dose-Dependent Toxicity of Silica Nanoparticles in
   Hepatocytes.
   Advanced Materials Research, 2013 ,647, 42-5.
157.Wang W, Liu Z, Qu P, Zhou Z, Zeng Y, Fan J, Liu Y, Guo Y, Qiu J.
   Knockdown of Regulator of Cullins-1 (ROC1) Expression Induces Bladder Cancer Cell Cycle
   Arrest at the G2Phase and Senescence.
   PLoS One. 2013 May 8;8(5):e62734. doi: 10.1371/journal.pone.0062734. Print 2013.
158.Zhao C, Yin P, Mei C, Li N, Yao W, Li X, Qi J, Fan K, Li Z, Wang L, Shi Y, Qiu S,
   Fan J, Zha X.
   Down-regulation of DNA methyltransferase 3B in staurosporine-induced apoptosis and its
   mechanism in humanhepatocarcinoma cell lines.
   Mol Cell Biochem.2013 Apr; 376(1-2):111-9. doi: 10.1007/s11010-012-1556-8.
   Epub 2013 Feb 9.
159.Yu C, Xing F, Tang Z, Bronner C, Lu X, Di J, Zeng S, Liu J.
   Anisomycin suppresses Jurkat T cell growth by the cell cycle-regulating proteins.
   Pharmacol Rep. 2013;65(2):435-44.
160.Tang Y, Wang F, Jin C, Liang H, Zhong X, Yang Y.
   Mitochondrial injury induced by nanosized titanium dioxide in A549 cells and rats.
   Environ Toxicol Pharmacol. 2013 Jul;36(1):66-72. doi: 10.1016/j.etap.2013.03.006.
   Epub 2013 Mar 21.
161.Wang XX, Cheng Q, Zhang SN, Qian HY, Wu JX, Tian H, Pei DS, Zheng JN.
   PAK5-Egr1-MMP2 signaling controls the migration and invasion in breast cancer cell.
   Tumour Biol. 2013 May 22. [Epub ahead of print].
162.Pang XL, He G, Liu YB, Wang Y, Zhang B.
   Endoplasmic reticulum stress sensitizes human esophageal cancer cell to radiation.
   World J Gastroenterol. 2013 Mar 21;19(11):1736-48. doi: 10.3748/wjg.v19.i11.1736.
163.Zhang X, Guo WG, Cui H, Liu HY, Zhang Y, Müller WE, Cui FZ.
   In vitro and in vivo enhancement of osteogenic capacity in a synthetic BMP-2 derived
   peptide-coated mineralizedcollagen composite.
   J Tissue Eng Regen Med. 2013 Jan 31. doi: 10.1002/term.1705. [Epub ahead of print].
164.Kong CZ, Liu J, Liu L, Zhang Z, Guo KF.
   Interactional expression of netrin-1 and its dependence receptor UNC5B in prostate
   carcinoma.
   Tumour Biol. 2013 May 12. [Epub ahead of print].
165.Xie B, Zhou J, Shu G, Liu DC, Zhou J, Chen J, Yuan L.
   Restoration of klotho gene expression induces apoptosis and autophagy in gastric cancer
   cells: tumorsuppressive role of klotho in gastric cancer.
   Cancer Cell Int. 2013 Feb 21;13(1):18. doi: 10.1186/1475-2867-13-18.
166.Luo DY, Wazir R, Tian Y, Yue X, Wei TQ, Wang KJ.
   Integrin αv mediates contractility whereas integrin α4 regulates proliferation of
   human bladder smooth musclecells via FAK pathway under physiological stretch.
   J Urol. 2013 Apr 12. pii: S0022-5347(13)04073-1.
167.Tang Y, Tan B, Xiong X, Li F, Ren W, Kong X, Qiu W, Hardwidge PR, Yin Y.
   Methionine deficiency reduces autophagy and accelerates death in intestinal epithelial
   cells infected with enterotoxigenic Escherichia coli.
   Amino Acids. 2014 Jun 26.
168.Cai W, Dong F, Wang Z, Yang X, Zheng M, Che X.
   Heated and humidified CO₂ pneumoperitoneum inhibits tumour cell proliferation, migration
   and invasion in colon cancer.
   Int J Hyperthermia. 2014 May;30(3):201-9. doi: 10.3109/02656736.2014.898339. Epub
   2014 Apr 10.
169.Zhang GH, Qin R, Zhang SH, Zhu H.
   Effects of vascular endothelial growth factor B on proliferation and migration in
   EA.Hy926 cells.
   Mol Biol Rep. 2014 Feb;41(2):779-85. doi: 10.1007/s11033-013-2917-4. Epub 2013 Dec 30.
170.Ben Q, An W, Fei J, Xu M, Li G, Li Z, Yuan Y.
   Downregulation of L1CAM inhibits proliferation, invasion and arrests cell cycle
   progression in pancreatic cancer cells in vitro.
   Exp Ther Med. 2014 Apr;7(4):785-790. Epub 2014 Feb 5.
171.Yang X, Zhu H, Ge Y, Liu J, Cai J, Qin Q, Zhan L, Zhang C, Xu L, Liu Z, Yang Y, Yang Y,
   Ma J, Cheng H, Sun X.
   Melittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by
   suppressing HIF-1α.
   Tumour Biol. 2014 Jul 23.
172.Shao S, Li S, Qin Y, Wang X, Yang Y, Bai H, Zhou L, Zhao C, Wang C.
   Spautin-1, a novel autophagy inhibitor, enhances imatinib-induced apoptosis in chronic
   myeloid leukemia.
   Int J Oncol. 2014 May;44(5):1661-8. doi: 10.3892/ijo.2014.2313. Epub 2014 Feb 27.
173.Xu YY, Wu TT, Zhou SH, Bao YY, Wang QY, Fan J, Huang YP.
   Apigenin suppresses GLUT-1 and p-AKT expression to enhance the chemosensitivity to
   cisplatin of laryngeal carcinoma Hep-2 cells: an in vitro study.
   Int J Clin Exp Pathol. 2014 Jun 15;7(7):3938-47. eCollection 2014.
174.Wang F, Xu H, Wang Y, Wang R, Yuan L, Ding H, Song C, Ma S, Peng Z, Peng Z, Zhao P,
   Xia Q.
   Advanced silk material spun by a transgenic silkworm promotes cell proliferation for
   biomedical application.
   Acta Biomater. 2014 Jun 28. pii: S1742-7061(14)00287-6. doi: 10.1016/j.actbio.2014.
   06.031.
175.Ma S, Liang S, Jiao H, Chi L, Shi X, Tian Y, Yang B, Guan F.
   Human umbilical cord mesenchymal stem cells inhibit C6 glioma growth via secretion of
   dickkopf-1 (DKK1).
   Mol Cell Biochem. 2014 Jan;385(1-2):277-86. doi: 10.1007/s11010-013-1836-y. Epub 2013
   Oct 9.
176.Cai XY, Xiong LM, Yang SH, Shao ZW, Xie M, Gao F, Ding F.
   Comparison of toxicity effects of ropivacaine, bupivacaine, and lidocaine on rabbit
   intervertebral disc cells in vitro.
   Spine J. 2014 Mar 1;14(3):483-90. doi: 10.1016/j.spinee.2013.06.041. Epub 2013 Aug 23.
177.Feng X, Lu X, Huang D, Xing J, Feng G, Jin G, Yi X, Li L, Lu Y, Nie D, Chen X, Zhang L,
   Gu Z, Zhang X.
   3D porous chitosan scaffolds suit survival and neural differentiation of dental pulp
   stem cells.
   Cell Mol Neurobiol. 2014 Aug;34(6):859-70. doi: 10.1007/s10571-014-0063-8. Epub 2014
   May 1.
178.Li Y, Wang S, Wang Z, Qian X, Fan J, Zeng X, Sun Y, Song P, Feng M, Ju D.
   Cationic poly(amidoamine) dendrimers induced cyto-protective autophagy in hepatocellular
   carcinoma cells.
   Nanotechnology. 2014 Aug 20;25(36):365101.
179.Guo D, Zhao Y, Zhang Y, Wang Q, Huang Z, Ding Q, Guo Z, Zhou X, Zhu L, Gu N.
   The cellular uptake and cytotoxic effect of silver nanoparticles on chronic myeloid
   leukemia cells.
   J Biomed Nanotechnol. 2014 Apr;10(4):669-78.
180.Duan S, Yang X, Mei F, Tang Y, Li X, Shi Y, Mao J, Zhang H, Cai Q.
   Enhanced osteogenic differentiation of mesenchymal stem cells on poly(l-lactide)
   nanofibrous scaffolds containing carbon nanomaterials.
   J Biomed Mater Res A. 2014 Jul 21. doi: 10.1002/jbm.a.35283.
181.Li L, Lin M, Li L, Wang R, Zhang C, Qi G, Xu M, Rong R, Zhu T.
   Renal telocytes contribute to the repair of ischemically injured renal tubules.
   J Cell Mol Med. 2014 Jun;18(6):1144-56. doi: 10.1111/jcmm.12274. Epub 2014 Apr 24.
182.Li PP, Yao QM, Zhou H, Feng LL, Ge XL, Lv X, Chen N, Lu K, Wang X.
   Metadherin contribute to BCR signaling in chronic lymphocytic leukemia.
   Int J Clin Exp Pathol. 2014 Mar 15;7(4):1588-94. eCollection 2014.
183.Shi Y, Yu P, Zeng D, Qian F, Lei X, Zhao Y, Tang B, Hao Y, Luo H, Chen J, Tan Y.
   Suppression of vascular endothelial growth factor abrogates the immunosuppressive
   capability of murine gastric cancer cells and elicits antitumor immunity.
   FEBS J. 2014 Sep;281(17):3882-93. doi: 10.1111/febs.12923. Epub 2014 Aug 19.
184.Wang B, Lin Q, Shen C, Tang J, Han Y, Chen H.
   Hydrophobic modification of polymethyl methacrylate as intraocular lenses material to
   improve the cytocompatibility.
   J Colloid Interface Sci. 2014 Oct 1;431:1-7. doi: 10.1016/j.jcis.2014.05.056. Epub
   2014 Jun 13.