|
|||||||||
产品简介
产品简介：
| 产品编号 | 产品名称 | 产品包装 | 产品价格 |
| S1643 | H-89(PKA抑制剂) | 1mg | 169.00元 |
H-89也称H89，全称为N-[2-(p-Bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide·2HCl
hydrate，是一种常用的PKA抑制剂。H-89可以通透细胞，可以选择性抑制cAMP、cGMP依赖的蛋白激酶PKA、PKG和PKCμ，但对于PKA的选择性抑制作用更强。
H-89分子量为519.28，分子式为C20H20BrN3O2S·2HCl，CAS Number：127243-85-0。本产品纯度大于
98%。
本H-89为进口分装，用DMSO配制，浓度为10mg/ml，接近20mM，共0.1ml。
包装清单：
产品编号 |
产品名称 |
包装 |
S1643 |
H-89(PKA抑制剂,10mg/ml) |
1mg |
— |
说明书 |
1份 |
保存条件：
-20℃保存，一年有效。
注意事项：
本产品对人体有害，操作时请小心，并注意有效防护以避免直接接触人体或吸入体内。
本H-89在4℃、冰浴等较低温度情况下会凝固而粘在离心管管底、管壁或管盖内，可以20-25℃水浴温育片刻至全部融解后使用。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
使用说明
使用说明：
1. H-89常见使用浓度范围为10-30μM，也有报道在1-50μM范围内使用。具体的最佳工作浓度请参考相关文
献，或根据实验目的，以及所培养的特定细胞和组织，通过实验进行摸索和优化。
产品图片
相关产品
相关论文
使用本产品的文献：
1. Yu Y, Liu L, Wang X, Liu X, Liu X, Xie L, Wang G.
Modulation of glucagon-like peptide-1 release by berberine: in vivo and in vitro
studies.
Biochem Pharmacol. 2010;79(7):1000-6.
2. Li Y, Kang Z, Li S, Kong T, Liu X, Sun C.
Ursolic acid stimulates lipolysis in primary-cultured rat adipocytes.
Mol Nutr Food Res. 2010 Nov;54(11):1609-17.
3. Jiang Z, Li S, Liu Y, Deng P, Huang J, He G.
Sesamin induces melanogenesis by microphthalmia-associated transcription factor and
tyrosinaseup-regulation via cAMP signaling pathway.
Acta Biochim Biophys Sin (Shanghai). 2011 Oct;43(10):763-70.
4. Zhang Q, Lu YQ, Jiang JK, Gu LH, Mou HZ.
Early changes of CD4+CD25+Foxp3+ regulatory T cells and Th1/Th2, Tc1/Tc2 profiles in
theperipheral blood of rats with controlled hemorrhagic shock and no fluid
resuscitation.
Chin Med J (Engl). 2012 Jun;125(12):2163-7.
5. Li J, Li Z, Tang L, Yang Y, Zouine M, Bouzayen M.
A conserved phosphorylation site regulates the transcriptional function of
ETHYLENE-INSENSITIVE3-like1 in tomato.
J Exp Bot. 2012 Jan;63(1):427-39.
6. Liu Y, Su Y, Sun S, Wang T, Qiao X, Li H, Run X, Liang Z.
Human tau may modify glucocorticoids-mediated regulation of cAMP-dependent kinase
andphosphorylated cAMP response element binding protein.
Neurochem Res. 2012 May;37(5):935-47.
7. Li Y, He J, Sui S, Hu X, Zhao Y, Li N.
Clenbuterol upregulates histone demethylase JHDM2a via the β(2)-adrenoceptor/cAMP/PKA
/p-CREB signaling pathway.
Cell Signal. 2012 Jul 20.
8. Mu X, He K, Sun H, Zhou X, Chang L, Li X, Chu W, Qiao G, Lu Y.
Hydrogen peroxide induces overexpression of angiotensin-converting enzyme in human
umbilical veinendothelial cells.
Free Radic Res. 2013 Feb;47(2):116-22. doi: 10.3109/10715762.2012.749987.
Epub 2012 Dec 10.
9. Chen Y, Su Y, Run X, Sun Z, Wang T, Sun S, Liang Z.
Pretreatment of PC12 Cells with 17β-estradiol Prevents Aβ-Induced Down-Regulation of
CREB Phosphorylationand Prolongs Inhibition of GSK-3β.
J Mol Neurosci. 2013 Jul;50(3):394-401. doi: 10.1007/s12031-012-9938-7.
Epub 2012 Dec 25.
10.Chen ML, Yi L, Jin X, Liang XY, Zhou Y, Zhang T, Xie Q, Zhou X, Chang H, Fu YJ, Zhu JD,
Zhang QY, Mi MT.
Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through
the cAMP signaling pathway.
Autophagy. 2013 Dec;9(12):2033-45. doi: 10.4161/auto.26336. Epub 2013 Sep 30.
11.Ouyang C, Nie L, Gu M, Wu A, Han X, Wang X, Shao J, Xia Z.
Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) activation requires
phosphorylation of serine 412 by protein kinase A catalytic subunit α (PKACα) and
X-linked protein kinase (PRKX).
J Biol Chem. 2014 Aug 29;289(35):24226-37. doi: 10.1074/jbc.M114.559963. Epub 2014 Jul
15.
12.Du XH, Zhou XL, Cao R, Xiao P, Teng Y, Ning CB, Liu HL.
FSH-induced p38-MAPK-mediated dephosphorylation at serine 727 of the signal transducer
and activator of transcription 1 decreases Cyp1b1 expression in mouse granulosa cells.
Cell Signal. 2015 Jan;27(1):6-14. doi: 10.1016/j.cellsig.2014.10.002. Epub 2014 Oct
12.
13.Wang Z, Zhang X, Tian H, Wang W, Ru S.
Effects of monocrotophos pesticide on steroidogenesis and transcription of steroidogenic
enzymes in rainbow trout RTG-2 cells involving the protein kinase A signal pathway.
Toxicol In Vitro. 2015 Feb;29(1):155-61. doi: 10.1016/j.tiv.2014.10.001. Epub 2014
Oct 12.
 苏ICP备06009238号 |